PMCH Seminar Series
Oct 06, 2011
Abstract: Blood flow restriction (BFR) to a contracting muscle during low-intensity resistance exercise training increases muscle strength and size in humans. However, the mechanism(s) responsible for how BFR exercise causes muscle hypertrophy are not known. We have previously shown that mTORC1 signaling and muscle protein synthesis (MPS) are stimulated following an acute bout of BFR exercise. As nutrients are also capable of activating mTORC1 signaling and MPS, we hypothesized that reactive hyperemia (i.e., enhanced nutritive blood flow) following BFR exercise would be an important mechanism for BFR exercise-induced muscle growth. We simulated the reactive hyperemia response from BFR exercise by infusing sodium nitroprusside (SNP), a pharmacological vasodilator, into the femoral artery after non-restricted low-intensity leg extension exercise. In a randomized cross-over design, the acute post-exercise mTORC1 signaling and MPS response, from six young men (24 ± 2y), was measured in the SNP group and compared to BFR exercise (BFR group). Post-exercise mixed muscle fractional synthetic rate from the vastus lateralis increased by 49% in the BFR group (P<0.05) but was unaffected in the SNP group (P>0.05). BFR exercise increased the phosphorylation of mTOR, S6K1, rpS6, ERK1/2 and Mnk1 (P<0.05). There were no changes in mTORC1 signaling in the SNP group (P>0.05). We conclude that reactive hyperemia is not a primary mechanism for BFR exercise-induced mTORC1 signaling and MPS. It remains to be determined whether mTORC1 signaling is required for the increase in MPS and muscle growth with BFR exercise.
Congratulations Naiomi Jamal!!
Please join me in congratulating Naiomi Jamal on her 2016 President's Cabinet Award! She received this for her program focused on Parent Based Teen Pregnancy Prevention. This is a very prestigious award - Congratulations Naiomi!
Congratulations LJ Panas on your new job at Kansas Health Institute!!
Lawrence John Panas, Ph.D., Senior Analyst, joined KHI in 2016 after earning a doctorate degree in population health sciences and a master's degree in public Health from UTMB. His work at UTMB focused on community health improvement and also on public health systems and services. Prior to joining KHI, he was a graduate/research assistant at the UTMB. During that time, Lawrence was also involved in a wide range of work related to issues such as aging, disability, mortality, minority health and health disparities.
Congratulations to Zakkoyya Lewis on your new job at Beachbody, LLC.
Zakkoyya (Koyya) Lewis accepted a position at Beachbody, LLC as their Fitness Research Manager in their Fitness and Nutrition Results department. This position is the first of its kind. As the Fitness Research Manager, Koyya is responsible for standardizing the measurement protocols for test groups on new products sponsored by Beachbody. She is responsible for the collection and evaluation of all test group data. It is also her responsibility to ensure that claims on new fitness programs meet scientific standards. In addition to running test groups, Koyya works directly with UTMB alum Erin Glynn, PhD and Research & Development as well as Digital Productions. She works as a liaison between departments to identify ways to improve programs and motivate customers.
Congratulations Dr. Arcari and Dr. Rudkin!!
Please join me in congratulating SOM Year 2 student Lynda Chowdhury and Drs. Arcari and Rudkin on their 2016 President's Cabinet Award! They received this for their application titled Health Fair Kits To Go: Turning Service into Service Learning. This is another very prestigious award for our department - Congratulations Lynda, Dr. Arcari, and Dr. Rudkin!
Please join us in wishing Joseph Saenz, PhD a farewell as he embarks on a new adventure.
Joseph Saenz obtained his PhD and is going to be a Post-Doctoral Fellow at the University of Southern California, Davis School of Gerontology, working with Dr. Eileen Crimmins and colleagues.
During his PhD stay at UTMB Department of Preventive Medicine and Community Health, and SCOA, he published several papers on aging among U.S. Hispanics and Mexicans. He consistently made presentations in local, national, and international professional meetings and conferences, winning several honors and awards.
At SCOA, he also coordinated the MHAS research work group.
We will miss him for his great scholarship, extraordinary citizenship, and personal disposition!