The “Gulf Coast Health Alliance: health Risks related to the Macondo Spill (GC-HARMS)” consortium involves the University of Texas Medical Branch, the University of Pennsylvania, Texas A&M University at Galveston, Louisiana State University, and Gulf Coast communities impacted by the Deepwater Horizon (DWH) disaster. The coalition of community partners are represented by the Louisiana Environmental Action Network (Baton Rouge, LA), the Center for Environmental and Economic Justice (Biloxi, MS), the Mississippi Coalition for Vietnamese-American Fisherfolk and Families (Gulfport, MS), the United Houma Nation (Houma, LA), Bayou Interfaith Shared Community Organizing (Thibodeaux, LA), and the Alabama Fisheries Cooperative (Coden, AL). The mission of the GC-HARMS consortium is to explore the health impacts and community resiliency related to the DWH disaster by fostering collaborative interactions amongst multi-disciplinary, multi-institutional basic and clinical investigators—buttressed by active participation of various community partners—to pursue both fundamental and translational research pertinent to the effects of the oil spill on human health. The overall theme of the GC-HARMS consortium is to understand and communicate the human health risks of exposure to potentially hazardous food-borne petrogenic Polycyclic Aromatic Hydrocarbons (PAH). Our goals developed in collaboration with our community partners are to, 1) assess PAH contamination of Gulf seafood consumed by and sold by the subsistence fishing communities, 2) determine the toxicity of petrogenic PAH, 3) evaluate exposure and health outcomes in the human population, and 4) translate and disseminate findings to our community stakeholders for development of appropriate outreach and education activities.